The Protein Dynamics and Flexibility by NMR Group (IBS/FDP) is seeking highly motivated post-doctoral researchers to study the functional modes of highly dynamic assemblies involved in the replication of pathogenic RNA viruses (SARS-CoV-2, Measles, Influenza).
The project lies at the interface of biology, chemistry and physics and will mainly exploit state-of-the-art NMR spectroscopy, together with MD simulation (atomic/coarse grained), fluorescence spectroscopy and imaging, X-ray crystallography, cryo-EM and SAXS.
The Project:
Despite major advances made over the last decade both in cryo-electron microscopy and in protein
structure prediction, a significant fraction of all proteomes remains beyond the reach of structural biology due to their highly
dynamic or disordered nature. NMR spectroscopy is the only tool capable of describing such systems at atomic resolution.
The molecular mechanisms regulating the functional modes of intrinsically disordered proteins (IDPs) remain poorly
understood. In this group they use state of the art NMR spectroscopy to describe the conformational dynamics of highly
disordered assemblies as a function of their environment (dilute, crowded, phase separated or in cellulo) and to map their
molecular interaction trajectories in time and space.
The successful candidate will join a multi-disciplinary team investigating the physical role of highly dynamic proteinsinvolved
in viral replication, in particular SARS-CoV-2, influenza virus and measles, and to exploit this information to develop novel
inhibitors, to crack the still unsolved challenge of ‘Drugging the Undruggable’.
The project lies at the interface of biology, chemistry and physics and will mainly exploit state-of-the-art NMR spectroscopy, together with MD simulation (atomic/coarse grained), fluorescence spectroscopy and imaging, X-ray crystallography, cryoEM and SAXS.
Applicant Requirements
Find out more information and details on how to apply here.
