ALPX is an EMBL Spin-off Company located in Grenoble, France. We offer innovative research services based on the CrystalDirect technology for structural biology and small-molecule drug discovery to the pharmaceutical and biotech industries.
We seek a highly experienced and motivated Protein Production specialist to join the ALPX team.
The successful candidate will be contributing to a range of exciting structural biology/drug discovery projects, and will be spearheading the development of our Protein Engineering and Production platform.
Responsibilities include planning, development, implementation and optimisation of Standard Operating Protocols for protein production, from expression to purification, for quality control, characterization, and construct optimisation. The position also requires strong oral and written communication skills as reports are to be prepared and shared to other ALPX Units (Cryo-EM and Macromolecular Crystallography) and to clients.
Required knowledge, skills, and abilities:
Ph.D. in chemistry, biology, physics, or a related field, with an excellent track record
Strong experience in protein expression in different organisms (E. coli, insect cells and human cells)
Deep knowledge of protein purification, in terms of techniques (affinity, chromatography, gel filtration)
and instruments (AKTA and BioRad systems)
Extensive practice in protein quality control (SDS-PAGE, Western Blot, cross-linking)
Experience in protein characterization by Mass Photometry, Size Exclusion Chromatography, Thermal
Shift Assay
Team player with the ability to work on several projects in parallel
Strong oral and written communication and organisation skills
Excellent written and speaking English
Preferred knowledge, skills, and abilities:
Proved experience in AI assisted construct design, gene optimization and directed mutagenesis
Demonstrated ability to work on challenging targets, such as membrane proteins
Previous position(s) in Industry/CRO/CMO
The position is permanent and immediately available. Deadline for application: July 10 2025.
If you are enthusiastic about this position but find that your previous experience does not precisely match every
requirement outlined in the job description, we still encourage you to apply. We are looking forward to hearing from you.
http://alpx-services.com
