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Instruct PartnerTopic: Sample requirements and specimen optimization for single-particle cryo-EM: What to consider with Christos Savva
Time: Thursday May 22nd, 2025, 05:00 EST / 10:00 WEST / 11:00 (Belgium) CEST / 12:00 IDT (Israel) / 14:30 IST (India) / 17:00 (SGT) / 18:00 JST / 19:00 AEST / 20:00 AEDT
Single-particle Cryo-EM (SPA) has become a leading method for determining high-resolution structures of macromolecular complexes, driven by recent technological advancements. However, a significant bottleneck persists, primarily due to challenges in achieving high-quality samples, both from a biochemical and specimen preparation aspect. This presentation will outline the essential sample requirements for a feasible SPA project and highlight the obstacles that can arise even after achieving biochemical optimization. Finally, we will explore recent advancements aimed at improving and automating specimen preparation to overcome this critical limitation.
https://zoom.us/j/95006268193?pwd=G8ivZfFa1Hitd8cOcDfIGgXzu5viXz.1
Meeting ID: 950 0626 8193
Passcode: 891668
